In cases of persistent hypotension due to Calcium Channel Blocker overdose, what is the recommended treatment?

In cases of persistent hypotension resulting from Calcium Channel Blocker overdose, the recommended treatment of Calcium Chloride 1 gram IV is effective because it addresses the specific physiological impact of calcium channel blockers. These medications primarily work by inhibiting calcium entry into cells, which can lead to decreased cardiac contractility and vascular smooth muscle relaxation, ultimately contributing to hypotension.

Calcium Chloride helps to counteract this effect by providing an immediate source of calcium, which is essential for the contraction of cardiac muscle fibers and smooth muscle. By restoring calcium levels in the bloodstream, Calcium Chloride can help to improve myocardial contractility and vascular tone, which may alleviate hypotension.

While the other treatments have their uses in various medical scenarios, they do not directly address the underlying issue of calcium depletion caused by the overdose. For instance, Atropine is useful for bradycardia but may not significantly impact hypotension due to calcium channel blockade. Sodium Bicarbonate is generally used to treat metabolic acidosis, and while it can help in certain overdose situations, it is not the primary treatment for managing hypotension from calcium channel blockers. Magnesium Sulfate can be beneficial in managing seizures or certain arrhythmias but is not a first-line treatment for calcium channel blocker overdose