What is the maximum dose of Benadryl for adults experiencing Phenothiazine poisoning?

In cases of Phenothiazine poisoning, the use of Benadryl (Diphenhydramine) is recommended as an antidote due to its anticholinergic properties, which can help counteract the effects of the overdose. The correct choice pertains to the maximum dose of Benadryl administered via the intramuscular (IM) route.

For adults experiencing Phenothiazine poisoning, the recommended maximum dose is 50 mg IM. This dosing is based on clinical guidelines that suggest this amount can effectively mitigate the symptoms associated with the toxicity of Phenothiazines, such as severe agitation, dystonia, or extrapyramidal symptoms. Administering this dose intramuscularly allows for adequate absorption into the bloodstream, providing rapid therapeutic relief.

Other routes and dosages presented may not align with the standard recommendations for this specific situation. For example, doses given intravenously may have different protocols and risks associated with them. In this context, 50 mg IM is the most effective and safest dosing practice based on existing guidelines for managing this type of poisoning.